My 5" label is printing sideways on label and should be left to right. This is a New set up for this size.

SOURCE: Zebra 105sl - printer does not print correct size

This can happen if you have the wrong dpi setup. For instance the 105sl can be either 203dpi or 300dpi. If your printhead is 300dpi and the label you create is expecting 203dpi, then you will see shrunken label. Your situation doesn't exactly sound like this is the case but it may be worth checking.

SOURCE: Labels print out of center

the important thing is if you are using different type labels and sizes before printing see to it that the labels must properly calibrated..to avoid printing incorrectly

SOURCE: Labels print out of position

Try cleaning the media and ribbon sensor you can open it and try clean it, it possible that there's a lot of dust or even small particles at the sensor path..

SOURCE: I have a zebra 2844 - it finally prints the right

It is because you do not have a factory original power supply. If you watch the printer or power light on the power supply I would bet it turns off and then back on again. Don't pay attention to the power supply specs they can be weak. Get a Hitek Plus 120 or 220 or FSP50-11 it will work. Good Luck.

SOURCE: Trying to Print USPS Labels from PayPal on TLP 2844

see if you can set the printer preferences to borderless printing.