Can you drive in 2 wheel drive in jeep gran cherokee 4,7 2001

Have the front end checked for excessive worn parts, tie rods ends may be worn out, Also uneven worn tires can cause this and alignment issues like incorrect caster.

that is because you have Part time 4wd? (what do you have)?
and must not drive on pavement free of ice.
its now winding up the drive train, bad for it too.

drive, to dirt, sand, gavel or grass and shift out of 4wd.
or jack up 1 tire, and same,
one tire must be on slippery surface. at least.

http://www.rubicon-trail.com/4WD101/driveline-bind.html

this happens on all PT 4wd
or using LOCK on AWD. dont.

Check the soildnoid that engages 4x4 by switching it from 2 to 4 wheel drive and listen to it 27 dollar part if needed to be replaced

sounds like the transfer case is broken.

If your in 4 low be sure to shift into nuetral first. Otherwise try backing up while shifting to 2 wheel drive

CHECK THE ABS TONE RINGS ON FRONT CV AXLES..OUT ON AXLE AXLE END NEAR WHEEL BEARING..HAVE SLOTS OR TEETH..ONE MAY BE CRACKED AND GIVING AN ERRATIC SPEED SIGNAL TO ABS MODULE..CAN BE AN INTERMITTENT PROBLEM

check your linkage bolt first. if it has came loose you will need to make sure it is set to be in 2 wheel drive.first make sure your shift lever is in the 2 wheel drive postion then crawl under the jeep loosen the nut move the lever all the way forward (front of the jeep) this is 4 low , move it back one notch and this is netural, move it back one more and this is 4 high, move it one more notch this is 2 wheel drive. tighten the bolt. this should get you back on the road.

You can't put the transfercase in nuetral the car won't move its prolly a all time 4-wheel drive if there isn't a 2-wheel sign on the gear shifer then it's a all the time 4- wheel drive

put it in 2 wheel drive a drive in reverse for about 5-8 ft and this should unbind it.......good luck!

No, not with out a lot of work. Electronics are most likely different on the 2 also.