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Could be a vacuum leak have you done a compression test if you have low compressin in a cylinder will cause that also if compression is good and no vacuum leaks look at the injectors and injector harness
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Misfires can also be caused by air flow issues and fuel supply issues. Have you had the vehicle scanned for OBD Trouble Codes to check this isn't a faulty sensor causing the problem. Check the fuel injectors are all firing correctly.
When was the engine last serviced? A dirty air filter can cause more issues than you would expect.
google the engine make for the firing order
p0300 is random misfires and is seldom plugs and wires but more likely to be low fuel pressure ( dirty filter) or blocked injectors
TAKE IT TO NOONE ELSE BUT A CHEVY DEALERSHIP AND HAVE THEM RUN A DIAG GIVE YOU AN ESTIMATE. I LOVE THOSE OLD CHEVY ASTRO VANS I HAVE HAD 3 OF THEM. SIMETIMES IT IS CHEAPER TO JUST REPLACE THE OLD VANS RATHER THEN SPEND MONEY ON THEM. THE LAST VAN I HAD I HAD PUT OVER 700,000 MILES ON IT BEFORE I GOT RID OF IT.
could be your coil, but can also be internal, have you replaced both the air & fuel filters ? if so, dump some good fuel injector cleaner into tank when half empty , top off with 91-92 octane fuel, see how that works for you, do some highway driving, stop & go traffic creates problems, todays fuel w/ethonal is bad for older cars, be sure to have code cleared from ecm !
The easiest way personally to check for a misfire is (with old set of plug wires though) ground a test light. Poke through each plug boot at distributor. If it makes engine miss more not a problem cylinder. When you get to one where there is no change, that is the cylinder that is missing. Not saying that it will cure your problem, but it would rule out the good cylinders that are operating correctly. Make sure you don't touch bare metal because it will shock you. It might not miss either unless under load. Firing order is 18436572 ccw on cap. 1 cylinder drivers side closest to radiator. Drivers side 1357,passenger side 2468. Looking from front of engine to back of engine.
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